ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk.

ABSTRACT: Schizophrenia (SCZ) is known to be a heritable disorder; however, its multifactorial nature has significantly hampered attempts to establish its pathogenesis. Therefore, in this study, we performed genome-wide copy-number variation (CNV) analysis of 2940 patients with SCZ and 2402 control subjects and identified a statistically significant association between SCZ and exonic CNVs in the ARHGAP10 gene. ARHGAP10 encodes a member of the RhoGAP superfamily of proteins that is involved in small GTPase signaling. This signaling pathway is one of the SCZ-associated pathways and may contribute to neural development and function. However, the ARHGAP10 gene is often confused with ARHGAP21, thus, the significance of ARHGAP10 in the molecular pathology of SCZ, including the expression profile of the AR

SUBMITTER: Sekiguchi M 

PROVIDER: S-EPMC7376022 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature