Trisk 95 as a novel skin mirror for normal and diabetic systemic glucose level.

ABSTRACT: Developing trustworthy, cost effective, minimally or non-invasive glucose sensing strategies is of great need for diabetic patients. In this study, we used an experimental type I diabetic mouse model to examine whether the skin would provide novel means for identifying biomarkers associated with blood glucose level. We first showed that skin glucose levels are rapidly influenced by blood glucose concentrations. We then conducted a proteomic screen of murine skin using an experimental in vivo model of type I diabetes and wild-type controls. Among the proteins that increased expression in response to high blood glucose, Trisk 95 expression was significantly induced independently of insulin signalling. A luciferase reporter assay demonstrated that the induction of Trisk 95 expression occurs a

SUBMITTER: Ali N 

PROVIDER: S-EPMC7376074 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature