Applying dimensional psychopathology: transdiagnostic associations among regional homogeneity, leptin and depressive symptoms.

ABSTRACT: Dimensional psychopathology and its neurobiological underpinnings could provide important insights into major psychiatric disorders, including major depressive disorder, bipolar disorder and schizophrenia. In a dimensional transdiagnostic approach, we examined depressive symptoms and their relationships with regional homogeneity and leptin across major psychiatric disorders. A total of 728 participants (including 403 patients with major psychiatric disorders and 325 age-gender-matched healthy controls) underwent resting-state functional magnetic resonance imaging at a single site. We obtained plasma leptin levels and depressive symptom measures (Hamilton Depression Rating Scale (HAMD)) within 24 h of scanning and compared the regional homogeneity (ReHo), plasma leptin levels and HAMD total

SUBMITTER: Wei YG 

PROVIDER: S-EPMC7376105 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature