Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome.

ABSTRACT: Polycystic ovary syndrome (PCOS) is characterized by androgen excess, ovulatory dysfunction and polycystic ovaries¹, and is often accompanied by insulin resistance². The mechanism of ovulatory dysfunction and insulin resistance in PCOS remains elusive, thus limiting the development of therapeutics. Improved metabolic health is associated with a relatively high microbiota gene content and increased microbial diversity^3,4. This study aimed to investigate the impact of the gut microbiota and its metabolites on the regulation of PCOS-associated ovarian dysfunction and insulin resistance. Here, we report that Bacteroides vulgatus was markedly elevated in the gut microbiota of individuals with PCOS, accompanied by reduced glycodeoxycholic acid and tauroursodeoxyc

SUBMITTER: Qi X 

PROVIDER: S-EPMC7376369 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature