The Impact of Toxicities on First-Year Outcomes after Ex Vivo CD34⁺-Selected Allogeneic Hematopoietic Cell Transplantation in Adults with Hematologic Malignancies.

ABSTRACT: Factors that impact first-year morbidity and mortality in adults undergoing myeloablative allogeneic hematopoietic cell transplantation with ex vivo CD34⁺ selection have not been previously reported. We assessed all toxicities ≥ grade 3 from the start of conditioning to date of death, relapse, or last contact in 200 patients during the first year after transplantation, identifying 1885 individual toxicities among 17 organ-based toxicity groups. The most prevalent toxicities in the first year were of infectious, metabolic, hematologic, oral/gastrointestinal, hepatic, cardiac, and pulmonary etiologies. Renal complications were minimal. Grades II to IV and III and IV acute GVHD at day 100 were 11.5% and 3%, respectively. In separate multivariate models, cardiovascular, hematologic,

SUBMITTER: Kosuri S 

PROVIDER: S-EPMC7376603 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature