Comparison of [¹⁸F]FDG PET/CT with magnetic resonance imaging for the assessment of human brown adipose tissue activity.

ABSTRACT:

Background

Brown adipose tissue (BAT) is a thermogenic tissue which can generate heat in response to mild cold exposure. As it constitutes a promising target in the fight against obesity, we need reliable techniques to quantify its activity in response to therapeutic interventions. The current standard for the quantification of BAT activity is [¹⁸F]FDG PET/CT. Various sequences in magnetic resonance imaging (MRI), including those measuring its relative fat content (fat fraction), have been proposed and evaluated in small proof-of-principle studies, showing diverging results. Here, we systematically compare the predictive value of adipose tissue fat fraction measured by MRI to the results of [¹⁸F]FDG PET/CT.

Methods

We analyzed the diagnostic reliability

SUBMITTER: Fischer JGW 

PROVIDER: S-EPMC7376767 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature