Molecular signature of eutopic endometrium in endometriosis based on the multi-omics integrative synthesis.

ABSTRACT:

Purpose

To synthesise data from genome-wide studies reporting molecular signature of eutopic endometrium through the phases of the menstrual cycle in endometriosis.

Methods

Extraction of data from publications reporting genetic signatures characterising endometrium associated with endometriosis. The nomenclature of extracted differentially expressed transcripts and proteins was adopted according to the HUGO Gene Nomenclature Committee (HGNC). Loci were further sorted according to the different phases of the menstrual cycle, i.e. menstrual (M), proliferative (P), secretory (S), early-secretory (ES), mid-secretory (MS), late-secretory (LS), and not specified (N/S) if the endometrial dating was not available. Enrichment analysis was performed using the DAVID bioinformatics tool

SUBMITTER: Prasnikar E 

PROVIDER: S-EPMC7376782 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature