The role of the Acanthamoeba castellanii Sir2-like protein in the growth and encystation of Acanthamoeba.

ABSTRACT:

Background

The encystation of Acanthamoeba leads to the development of resilient cysts from vegetative trophozoites. This process is essential for the survival of parasites under unfavorable conditions. Previous studies have reported that, during the encystation of A. castellanii, the expression levels of encystation-related factors are upregulated. However, the regulatory mechanisms for their expression during the encystation process remains unknown. Proteins in the sirtuin family, which consists of nicotinamide adenine dinucleotide-dependent deacetylases, are known to play an important role in various cellular functions. In the present study, we identified the Acanthamoeba silent-information regulator 2-like protein (AcSir2) and examined its role in the growth and encystation of

SUBMITTER: Joo SY 

PROVIDER: S-EPMC7376869 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature