Exploring Clinically-Relevant Experimental Models of Neonatal Shock and Necrotizing Enterocolitis.

ABSTRACT: Neonatal shock and necrotizing enterocolitis (NEC) are leading causes of morbidity and mortality in premature infants. NEC is a life-threatening gastrointestinal illness, the precise etiology of which is not well understood, but is characterized by an immaturity of the intestinal barrier, altered function of the adaptive immune system, and intestinal dysbiosis. The complexities of NEC and shock in the neonatal population necessitate relevant clinical modeling using newborn animals that mimic the disease in human neonates to better elucidate the pathogenesis and provide an opportunity for the discovery of potential therapeutics. A wide variety of animal species-including rats, mice, piglets, and primates-have been used in developing experimental models of neonatal diseases such as NEC and s

SUBMITTER: Nolan LS 

PROVIDER: S-EPMC7376956 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature