Intracranial alternating current stimulation facilitates neurogenesis in a mouse model of Alzheimer's disease.

ABSTRACT:

Background

Neurogenesis is significantly impaired in the brains of both human patients and experimental animal models of Alzheimer's disease (AD). Although deep brain stimulation promotes neurogenesis, it is an invasive technique that may damage neural circuitry along the path of the electrode. To circumvent this problem, we assessed whether intracranial electrical stimulation to the brain affects neurogenesis in a mouse model of Alzheimer's disease (5xFAD).

Methods and results

We used Ki67, Nestin, and doublecortin (DCX) as markers and determined that neurogenesis in both the subventricular zone (SVZ) and hippocampus were significantly reduced in the brains of 4-month-old 5xFAD mice. Guided by a finite element method (FEM) computer simulation to approximately estimate curre

SUBMITTER: Liu Q 

PROVIDER: S-EPMC7376967 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature