Remdesivir for 5 or 10 Days in Patients with Severe Covid-19.

ABSTRACT:

Background

Remdesivir is an RNA polymerase inhibitor with potent antiviral activity in vitro and efficacy in animal models of coronavirus disease 2019 (Covid-19).

Methods

We conducted a randomized, open-label, phase 3 trial involving hospitalized patients with confirmed SARS-CoV-2 infection, oxygen saturation of 94% or less while they were breathing ambient air, and radiologic evidence of pneumonia. Patients were randomly assigned in a 1:1 ratio to receive intravenous remdesivir for either 5 days or 10 days. All patients received 200 mg of remdesivir on day 1 and 100 mg once daily on subsequent days. The primary end point was clinical status on day 14, assessed on a 7-point ordinal scale.

Results

In total, 397 patients underwent randomization and began treatment (200

SUBMITTER: Goldman JD 

PROVIDER: S-EPMC7377062 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature