Cardiovascular Effects of Polychlorinated Biphenyls and Their Major Metabolites.

ABSTRACT:

Background

Xenobiotic metabolism is complex, and accounting for bioactivation and detoxification processes of chemicals remains among the most challenging aspects for decision making with in vitro new approach methods data.

Objectives

Considering the physiological relevance of human organotypic culture models and their utility for high-throughput screening, we hypothesized that multidimensional chemical-biological profiling of chemicals and their major metabolites is a sensible alternative for the toxicological characterization of parent molecules vs. metabolites in vitro.

Methods

In this study, we tested 25 polychlorinated biphenyls (PCBs) [PCB 3, 11, 52, 126, 136, and 153 and their relevant metabolites (hydroxylated, methoxylated, sulfated, and quinone

SUBMITTER: Grimm FA 

PROVIDER: S-EPMC7377239 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature