Candida albicans increases the pathogenicity of Staphylococcus aureus during polymicrobial infection of Galleria mellonella larvae.

ABSTRACT: This study detailed the responses of Galleria mellonella larvae to disseminated infection caused by co-infection with Candida albicans and Staphylococcus aureus. Doses of C. albicans (1×10⁵ larva^-1) and S. aureus (1×10⁴ larva^-1) were non-lethal in mono-infection but when combined significantly (P<0.05) reduced larval survival at 24, 48 and 72 h relative to larvae receiving S. aureus (2×10⁴ larva^-1) alone. Co-infected larvae displayed a significantly higher density of S. aureus larva^-1 compared to larvae infected solely with S. aureus. Co-infection resulted in dissemination throughout the host and the appearance of large nodules. Co-infection of larvae

SUBMITTER: Sheehan G 

PROVIDER: S-EPMC7377259 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature