HIV Modifies the Effect of Tobacco Smoking on Oral Human Papillomavirus Infection.

ABSTRACT:

Background

People living with HIV (PLWH) are more likely to smoke and harbor oral human papillomavirus (HPV) infections, putting them at higher risk for head and neck cancer. We investigated effects of HIV and smoking on oral HPV risk.

Methods

Consecutive PLWH (n = 169) and at-risk HIV-negative individuals (n = 126) were recruited from 2 US health centers. Smoking history was collected using questionnaires. Participants provided oral rinse samples for HPV genotyping. We used multivariable logistic regression models with interaction terms for HIV to test for smoking effect on oral HPV.

Results

PLWH were more likely to harbor oral HPV than HIV-negative individuals, including α (39% vs 28%), β (73% vs 63%), and γ-types (33% vs 20%). HIV infection positively modified the

SUBMITTER: Alli BY 

PROVIDER: S-EPMC7377295 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature