COVID-19 and associations with frailty and multimorbidity: a prospective analysis of UK Biobank participants.

ABSTRACT:

Background

Frailty and multimorbidity have been suggested as risk factors for severe COVID-19 disease.

Aims

We investigated, in the UK Biobank, whether frailty and multimorbidity were associated with risk of hospitalisation with COVID-19.

Methods

502,640 participants aged 40-69 years at baseline (54-79 years at COVID-19 testing) were recruited across UK during 2006-10. A modified assessment of frailty using Fried's classification was generated from baseline data. COVID-19 test results (England) were available for 16/03/2020-01/06/2020, mostly taken in hospital settings. Logistic regression was used to discern associations between frailty, multimorbidity and COVID-19 diagnoses, after adjusting for sex, age, BMI, ethnicity, education, smoking and number of comorbidity g

SUBMITTER: Woolford SJ 

PROVIDER: S-EPMC7377312 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature