Distinct patterns of brain Fos expression in Carioca High- and Low-conditioned Freezing Rats.

ABSTRACT:

Background

The bidirectional selection of high and low anxiety-like behavior is a valuable tool for understanding the neurocircuits that are responsible for anxiety disorders. Our group developed two breeding lines of rats, known as Carioca High- and Low-conditioned Freezing (CHF and CLF), based on defensive freezing in the contextual fear conditioning paradigm. A random selected line was employed as a control (CTL) comparison group for both CHF and CLF lines of animals. The present study performed Fos immunochemistry to investigate changes in neural activity in different brain structures among CHF and CLF rats when they were exposed to contextual cues that were previously associated with footshock.

Results

The study indicated that CHF rats expressed high Fos expression in t

SUBMITTER: Leon LA 

PROVIDER: S-EPMC7377485 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature