Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids.

ABSTRACT: The molecular basis of aging and of aging-associated diseases is being unraveled at an increasing pace. An extended healthspan, and not merely an extension of lifespan, has become the aim of medical practice. Here, we define health based on the absence of diseases and dysfunctions. Based on an extensive review of the literature, in particular for humans and C. elegans, we compile a list of features of health and of the genes associated with them. These genes may or may not be associated with survival/lifespan. In turn, survival/lifespan genes that are not known to be directly associated with health are not considered. Clusters of these genes based on molecular interaction data give rise to maps of healthspan pathways for humans and for C. elegans. Overlaying healthspan-relate

SUBMITTER: Moller S 

PROVIDER: S-EPMC7377848 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature