Protein and calorie restriction may improve outcomes in living kidney donors and kidney transplant recipients.

ABSTRACT: Previously, we and others showed that dietary restriction protects against renal ischemia-reperfusion injury in animals. However, clinical translation of preoperative diets is scarce, and in the setting of kidney transplantation these data are lacking. In this pilot study, we investigated the effects of five days of a preoperative protein and caloric dietary restriction (PCR) diet in living kidney donors on the perioperative effects in donors, recipients and transplanted kidneys. Thirty-five kidney donors were randomized into either the PCR, 30% calorie and 80% protein reduction, or control group without restrictions. Adherence to the diet and kidney function in donors and their kidney recipients were analyzed. Perioperative kidney biopsies were taken in a selected group of transplanted ki

SUBMITTER: Jongbloed F 

PROVIDER: S-EPMC7377854 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature