Identification of candidate miRNAs in early-onset and late-onset prostate cancer by network analysis.

ABSTRACT: The incidence of patients under 55 years old diagnosed with Prostate Cancer (EO-PCa) has increased during recent years. The molecular biology of PCa cancer in this group of patients remains unclear. Here, we applied weighted gene coexpression network analysis of the expression of miRNAs from 24 EO-PCa patients (38-45 years) and 25 late-onset PCa patients (LO-PCa, 71-74 years) to identify key miRNAs in EO-PCa patients. In total, 69 differentially expressed miRNAs were identified. Specifically, 26 and 14 miRNAs were exclusively deregulated in young and elderly patients, respectively, and 29 miRNAs were shared. We identified 20 hub miRNAs for the network built for EO-PCa. Six of these hub miRNAs exhibited prognostic significance in relapse-free or overall survival. Additionally, two of the hu

SUBMITTER: Parra-Medina R 

PROVIDER: S-EPMC7378055 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature