Immune expression signatures as candidate prognostic biomarkers of age and gender survival differences in cutaneous melanoma.

ABSTRACT: This study aims to investigate the difference of gene expression and its prognostic significance in younger women with melanoma. Significantly upregulated genes in tumors compared to normal skin tissues were extracted. Among these genes, genes that significantly affected survival according to expression level were selected, and pathway annotation was performed. The patient proportion with high/low expression of the most significant pathways was analyzed in each age (< 50, 50-59, ≥ 60) and gender group. Survival was analyzed according to age, gender, and pathways. The most significant pathways that were upregulated in tumor tissues and also had impacts on survival were programmed cell death protein [PD]-1, interferon-γ, and interferon-α/β pathways. In women, the immune signaling rate in pat

SUBMITTER: Kim YJ 

PROVIDER: S-EPMC7378165 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature