P53 isoform Δ113p53 promotes zebrafish heart regeneration by maintaining redox homeostasis.

ABSTRACT: Neonatal mice and adult zebrafish can fully regenerate their hearts through proliferation of pre-existing cardiomyocytes. Previous studies have revealed that p53 signalling is activated during cardiac regeneration in neonatal mice and that hydrogen peroxide (H₂O₂) generated near the wound site acts as a novel signal to promote zebrafish heart regeneration. We recently demonstrated that the expression of the p53 isoform Δ133p53 is highly induced upon stimulation by low-level reactive oxygen species (ROS) and that Δ133p53 coordinates with full-length p53 to promote cell survival by enhancing the expression of antioxidant genes. However, the function of p53 signalling in heart regeneration remains uncharacterised. Here, we found that the expression of Δ113p53 is activate

SUBMITTER: Ye S 

PROVIDER: S-EPMC7378207 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature