Rhinovirus Infection Drives Complex Host Airway Molecular Responses in Children With Cystic Fibrosis.

ABSTRACT: Early-life viral infections are responsible for pulmonary exacerbations that can contribute to disease progression in young children with cystic fibrosis (CF). The most common respiratory viruses detected in the CF airway are human rhinoviruses (RV), and augmented airway inflammation in CF has been attributed to dysregulated airway epithelial responses although evidence has been conflicting. Here, we exposed airway epithelial cells from children with and without CF to RV in vitro. Using RNA-Seq, we profiled the transcriptomic differences of CF and non-CF airway epithelial cells at baseline and in response to RV. There were only modest differences between CF and non-CF cells at baseline. In response to RV, there were 1,442 and 896 differentially expressed genes in CF and non-CF airwa

SUBMITTER: Ling KM 

PROVIDER: S-EPMC7378398 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature