Differential regulation of hypoxanthine and xanthine by obesity in a general population.

ABSTRACT:

Aims/introduction

Uric acid is synthesized by oxidation of hypoxanthine and xanthine using a catalyzing enzyme, xanthine oxidoreductase (XOR), which can be a source of reactive oxygen species. Plasma XOR activity is a metabolic biomarker associated with obesity, hyperuricemia, liver dysfunction and insulin resistance. However, it has recently been reported that XOR activity in fat tissue is low in humans, unlike in rodents, and that hypoxanthine is secreted from human fat tissue.

Materials and methods

The associations of obesity with hypoxanthine, xanthine and plasma XOR activity were investigated in 484 participants (men/women: 224/260) of the Tanno-Sobetsu Study.

Results

Levels of hypoxanthine, xanthine and plasma XOR activity were significantly higher in men than i

SUBMITTER: Furuhashi M 

PROVIDER: S-EPMC7378426 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature