COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection.

ABSTRACT: Patients with coronavirus disease 2019 (COVID-19) have elevated D-dimer levels. Early reports describe high venous thromboembolism (VTE) and disseminated intravascular coagulation (DIC) rates, but data are limited. This multicenter retrospective study describes the rate and severity of hemostatic and thrombotic complications of 400 hospital-admitted COVID-19 patients (144 critically ill) primarily receiving standard-dose prophylactic anticoagulation. Coagulation and inflammatory parameters were compared between patients with and without coagulation-associated complications. Multivariable logistic models examined the utility of these markers in predicting coagulation-associated complications, critical illness, and death. The radiographically confirmed VTE rate was 4.8% (95% confidence inter

SUBMITTER: Al-Samkari H 

PROVIDER: S-EPMC7378457 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature