Serum proteome profiles revealed dysregulated proteins and mechanisms associated with fibromyalgia syndrome in women.

ABSTRACT: Fibromyalgia syndrome (FM) is a multifactorial disorder whose pathogenesis and diagnosis are poorly understood. This study investigated differential serum proteome profiles in patients with FM and healthy pain-free controls and explored the association between serum proteome and clinical profiles in patients with FM. Twenty patients with FM (according to the American College of Rheumatology criteria, 2010) and 20 healthy pain-free controls were recruited for optimized quantitative serum proteomics analysis. The levels of pain, pressure pain threshold, sleep, anxiety, depression, and functional status were evaluated for patients with FM. We identified 22 proteins differentially expressed in FM when compared with healthy pain-free controls and propose a panel of methyltransferase-like 18 (ME

SUBMITTER: Han CL 

PROVIDER: S-EPMC7378543 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature