Association of Initial Illness Severity and Outcomes After Cardiac Arrest With Targeted Temperature Management at 36 °C or 33 °C.

ABSTRACT:

Importance

It is uncertain what the optimal target temperature is for targeted temperature management (TTM) in patients who are comatose following cardiac arrest.

Objective

To examine whether illness severity is associated with changes in the association between target temperature and patient outcome.

Design, setting, and participants

This cohort study compared outcomes for 1319 patients who were comatose after cardiac arrest at a single center in Pittsburgh, Pennsylvania, from January 2010 to December 2018. Initial illness severity was based on coma and organ failure scores, presence of severe cerebral edema, and presence of highly malignant electroencephalogram (EEG) after resuscitation.

Exposure

TTM at 36 °C or 33 °C.

Main outcomes and measures

Primar

SUBMITTER: Callaway CW 

PROVIDER: S-EPMC7378753 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature