Risk of Schizophrenia and Bipolar Disorder in Patients With Multiple Sclerosis: Record-Linkage Studies.

ABSTRACT:

Background

The epidemiology of psychiatric comorbidity in multiple sclerosis (MS) remains poorly understood.

Objective

We aimed to determine the risk of schizophrenia and bipolar disorder in MS patients.

Material and methods

Retrospective cohort analyses were performed using an all-England national linked Hospital Episode Statistics (HES) dataset (1999-2016) and to determine whether schizophrenia or bipolar disorder are more commonly diagnosed subsequently in people with MS (n=128,194), and whether MS is more commonly diagnosed subsequently in people with schizophrenia (n=384,188) or bipolar disorder (n=203,592), than would be expected when compared with a reference cohort (~15 million people) after adjusting for age and other factors. Adjusted hazard ratios (aHRs) we

SUBMITTER: Meier UC 

PROVIDER: S-EPMC7378813 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature