Cranial irradiation at early postnatal age impairs stroke-induced neural stem/progenitor cell response in the adult brain.

ABSTRACT: Cranial irradiation (IR) is commonly used to treat primary brain tumors and metastatic diseases. However, cranial IR-treated patients often develop vascular abnormalities later in life that increase their risk for cerebral ischemia. Studies in rodents have demonstrated that IR impairs maintenance of the neural stem/precursor cell (NSPC) pool and depletes neurogenesis. We and others have previously shown that stroke triggers NSPC proliferation in the subventricular zone and migration towards the stroke-injured neocortex. Whether this response is sustained in the irradiated brain remains unknown. Here, we demonstrate that cranial IR in mice at an early postnatal age significantly reduced the number to neuronal progenitors responding to cortical stroke in adults. This was accompanied by a red

SUBMITTER: Neumann S 

PROVIDER: S-EPMC7378832 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature