Electronic Health Record-Embedded Decision Support Platform for Morphine Precision Dosing in Neonates.

ABSTRACT: Morphine is the opioid most commonly used for neonatal pain management. In intravenous form, it is administered as continuous infusions and intermittent injections, mostly based on empirically established protocols. Inadequate pain control in neonates can cause long-term adverse consequences; however, providing appropriate individualized morphine dosing is particularly challenging due to the interplay of rapid natural physiological changes and multiple life-sustaining procedures in patients who cannot describe their symptoms. At most institutions, morphine dosing in neonates is largely carried out as an iterative process using a wide range of starting doses and then titrating to effect based on clinical response and side effects using pain scores and levels of sedation. Our background data

SUBMITTER: Vinks AA 

PROVIDER: S-EPMC7378965 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature