Thermosensitive Micellar Hydrogels as Vehicles to Deliver Drugs With Different Wettability.

ABSTRACT: The design of adaptable drug delivery systems able to encapsulate and release drugs with different wettability has been attracting widespread interest. Additionally, many attempts have been made to tune hydrophobic/hydrophilic drug release kinetics over time, avoiding the so-called burst release. In this scenario, hydrogels resulting from the assembly of micellar structures showing a hydrophobic core and a hydrophilic shell could represent a promising alternative to design versatile drug vehicles. In this regard, this work aimed at designing new thermosensitive micellar hydrogels starting from a custom-made amphiphilic poly(ether urethane) (PEU). Specifically, a commercial triblock copolymer (Poloxamer^® 407), selected to ensure the temperature-driven chain arrangement int

SUBMITTER: Laurano R 

PROVIDER: S-EPMC7379125 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature