The evolving role of diet in prostate cancer risk and progression.

ABSTRACT:

Purpose of review

This overview examines the rationale for dietary interventions for prostate cancer by summarizing the current evidence base and biological mechanisms for the involvement of diet in disease incidence and progression.

Recent findings

Recent data have further solidified the association between insulin resistance and prostate cancer with the homeostatic model assessment of insulin resistance. Data also show that periprostatic adipocytes promote extracapsular extension of prostate cancer through chemokines, thereby providing a mechanistic explanation for the association observed between obesity and high-grade cancer. Regarding therapeutics, hyperinsulinemia may be the cause of resistance to phosphatidylinositol-3 kinase inhibitors in the treatment of prostate ca

SUBMITTER: Kaiser A 

PROVIDER: S-EPMC7379157 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature