Roles of microRNAs in mammalian reproduction: from the commitment of germ cells to peri-implantation embryos.

ABSTRACT: MicroRNAs (miRNAs) are active regulators of numerous biological and physiological processes including most of the events of mammalian reproduction. Understanding the biological functions of miRNAs in the context of mammalian reproduction will allow a better and comparative understanding of fertility and sterility in male and female mammals. Herein, we summarize recent progress in miRNA-mediated regulation of mammalian reproduction and highlight the significance of miRNAs in different aspects of mammalian reproduction including the biogenesis of germ cells, the functionality of reproductive organs, and the development of early embryos. Furthermore, we focus on the gene expression regulatory feedback loops involving hormones and miRNA expression to increase our understanding of germ cell com

SUBMITTER: Reza AMMT 

PROVIDER: S-EPMC7379200 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature