Insight into the bovine milk peptide LPcin-YK3 selection in the proteolytic system of Lactobacillus species.

ABSTRACT: Antimicrobial peptides are class of small, positively charged peptides known for their broad-spectrum antimicrobial activity. Antimicrobial activities for most antimicrobial peptides have largely remained elusive, particularly in the lactic acid bacteria. However, recently our investigation using LPcin-YK3, an antimicrobial peptide from bovine milk, suggests that in vitro antimicrobial activity was reduced over 100-fold compared with pathogenic bacteria. Additionally, for the structural study of how antimicrobial peptide undergoes its reaction at the proteolytic pathway of lactic acid bacteria based on degradation assay and propidium iodide staining, we performed molecular docking for interaction between oligopeptide-binding protein A and LPcin-YK3 peptide. Given that degradation related t

SUBMITTER: Sung WY 

PROVIDER: S-EPMC7379261 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature