Glycated hemoglobin concentrations of red blood cells minimally increase during storage under standard blood banking conditions.

ABSTRACT:

Background

Few and inconsistent data exist describing the effect of storage duration on glycated hemoglobin (HbA1c) concentrations of red blood cells (RBCs), impeding interpretation of HbA1c values in transfused diabetic patients. Hence the aim of this study was to evaluate to what extent HbA1c concentrations of RBCs change during the maximum allowed storage period of 42 days.

Study design and methods

Blood was drawn from 16 volunteers, leukofiltered, and stored under standard blood banking conditions. HbA1c concentrations of RBCs were measured on Days 1 and 42 of storage using three different validated devices (ion-exchange high-performance liquid chromatography Method A1 and A2, turbidimetric immunoassay Method B).

Results

Mean HbA1c concentrations of RBCs on Day 1

SUBMITTER: Prosenz J 

PROVIDER: S-EPMC7379282 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature