Curcumin inhibits the migration of osteoclast precursors and osteoclastogenesis by repressing CCL3 production.

ABSTRACT:

Background

Curcumin can inhibit the osteoclastogenesis and the migration of several cells including macrophages. Osteoclast precursors (OCPs) are known to exist as bone marrow-derived macrophages (BMMs). This study aims to explore whether curcumin can prevent the fusion and differentiation of OCPs to mature osteoclasts by inhibiting OCP migration.

Methods

In this study, we investigated the role of curcumin in regulating the production of several chemokines (CCL2, CCL3 and CX3CL1) and the migration of OCPs by ELISA, Western blotting and Transwell assays. Furthermore, we explored the role of curcumin in the chemokines-related osteoclastogenesis using pharmacological intervention and virus infection, and used ovariectomized (OVX) mice (osteoporosis model) to explore the effect

SUBMITTER: Liang Z 

PROVIDER: S-EPMC7379354 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature