Type 2 diabetes susceptibility genes on mouse chromosome 11 under high sucrose environment.

ABSTRACT:

Background

Both genetic and environmental factors contribute to type 2 diabetes development. We used consomic mice established from an animal type 2 diabetes model to identify susceptibility genes that contribute to type 2 diabetes development under specific environments. We previously established consomic strains (C3H-Chr 11^NSY and C3H-Chr 14^NSY) that possess diabetogenic Chr 11 or 14 of the Nagoya-Shibata-Yasuda (NSY) mouse, an animal model of spontaneous type 2 diabetes, in the genetic background of C3H mice. To search genes contribute to type 2 diabetes under specific environment, we first investigated whether sucrose administration deteriorates type 2 diabetes-related traits in the consomic strains. We dissected loci on Chr 11 by establishing congenic str

SUBMITTER: Kobayashi M 

PROVIDER: S-EPMC7379357 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature