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PIRs mediate innate myeloid cell memory to nonself MHC molecules.

ABSTRACT: Immunological memory specific to previously encountered antigens is a cardinal feature of adaptive lymphoid cells. However, it is unknown whether innate myeloid cells retain memory of prior antigenic stimulation and respond to it more vigorously on subsequent encounters. In this work, we show that murine monocytes and macrophages acquire memory specific to major histocompatibility complex I (MHC-I) antigens, and we identify A-type paired immunoglobulin-like receptors (PIR-As) as the MHC-I receptors necessary for the memory response. We demonstrate that deleting PIR-A in the recipient or blocking PIR-A binding to donor MHC-I molecules blocks memory and attenuates kidney and heart allograft rejection. Thus, innate myeloid cells acquire alloantigen-specific memory that can be targeted to improve transplant outcomes.

SUBMITTER: Dai H

PROVIDER: S-EPMC7379379 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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PIRs mediate innate myeloid cell memory to nonself MHC molecules.

Dai Hehua H Lan Peixiang P Zhao Daqiang D Abou-Daya Khodor K Liu Wentao W Chen Wenhao W Friday Andrew J AJ Williams Amanda L AL Sun Tao T Chen Jianjiao J Chen Wei W Mortin-Toth Steven S Danska Jayne S JS Wiebe Chris C Nickerson Peter P Li Tengfang T Mathews Lisa R LR Turnquist Hêth R HR Nicotra Matthew L ML Gingras Sebastien S Takayama Eiji E Kubagawa Hiromi H Shlomchik Mark J MJ Oberbarnscheidt Martin H MH Li Xian C XC Lakkis Fadi G FG

Science (New York, N.Y.) 20200507 6495

Immunological memory specific to previously encountered antigens is a cardinal feature of adaptive lymphoid cells. However, it is unknown whether innate myeloid cells retain memory of prior antigenic stimulation and respond to it more vigorously on subsequent encounters. In this work, we show that murine monocytes and macrophages acquire memory specific to major histocompatibility complex I (MHC-I) antigens, and we identify A-type paired immunoglobulin-like receptors (PIR-As) as the MHC-I recept ...[more]

PMID: 32381589

Dataset Information

PIRs mediate innate myeloid cell memory to nonself MHC molecules.

Publications

PIRs mediate innate myeloid cell memory to nonself MHC molecules.

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