Dynamic Interleukin-6 Level Changes as a Prognostic Indicator in Patients With COVID-19.

ABSTRACT:

Background

Interleukin-6 (IL-6), a proinflammatory cytokine, has been reported to be associated with disease severity and mortality in patients with coronavirus disease 2019 (COVID-19). Yet, dynamic changes in IL-6 levels and their prognostic value as an indicator of lung injury in COVID-19 patients have not been fully elucidated.

Objective

To validate whether IL-6 levels are associated with disease severity and mortality and to investigate whether dynamic changes in IL-6 levels might be a predictive factor for lung injury in COVID-19 patients.

Methods

This retrospective, single-center study included 728 adult COVID-19 patients and used data extracted from electronic medical records for analyses.

Results

The mortality rate was higher in the elevated IL-6 group

SUBMITTER: Liu Z 

PROVIDER: S-EPMC7379481 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature