ALDH^HIGH Population Is Regulated by the AKT/β-Catenin Pathway in a Cervical Cancer Model.

ABSTRACT: ALDH is an enzyme involved in different cellular processes, including cancer. It has been shown that a cellular subpopulation with high ALDH activity (ALDH^HIGH) within a tumor is related to functional capabilities such as stemness, chemoresistance, and tumorigenicity. However, few studies have focused on determining the mechanisms behind ALDH activity within the cells. Previously, our group reported that ALDH^HIGH cells have higher tumorigenicity in Cervical Cancer (CC) cell lines. Based on this, we were interested to know the molecular mediators of the ALDH^HIGH cells, specifically β-catenin, inasmuch as β-catenin is regulated through different pathways, such as Wnt signaling, and that it acts as a transcriptional co-activator involved in cancer progression.

SUBMITTER: Sarabia-Sanchez MA 

PROVIDER: S-EPMC7379485 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature