Postural Body Sway as Surrogate Outcome for Myelopathy in Adrenoleukodystrophy.

ABSTRACT:

Background

Myelopathy is the core clinical manifestation of adrenoleukodystrophy (ALD), which is the most common peroxisomal disorder. Development of therapies requires sensitive and clinically relevant outcome measures. Together with spastic paraparesis, balance disturbance is the main cause of disability from myelopathy in ALD. In this cross-sectional study, we evaluated whether postural body sway - a measure of balance - could serve as a surrogate outcome in clinical trials.

Methods

Forty-eight male ALD patients and 49 age-matched healthy male controls were included in this study. We compared sway amplitude and sway path of ALD patients to controls. We then correlated the body sway parameters showing the largest between-group differences with clinical measures of severity

SUBMITTER: van Ballegoij WJC 

PROVIDER: S-EPMC7379508 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature