Effect of different doses of inhaled ciclesonide on lung function, clinical signs related to airflow limitation and serum cortisol levels in horses with experimentally induced mild to severe airway obstruction.

ABSTRACT:

Background

Inhaled corticosteroids are effective for the treatment of equine asthma but they induce cortisol suppression with potential side effects.

Objectives

To study the efficacy of ciclesonide, an inhaled corticosteroid with an improved safety profile, on lung function, clinical signs related to airway obstruction, and serum cortisol levels in asthmatic horses exposed to a mouldy hay challenge.

Study design

Cross-over placebo controlled, blinded, randomised experiment.

Methods

Sixteen horses were enrolled in three subsequent dose-titration studies (8 horses/study) to investigate the effects of inhaled ciclesonide administered for 2 weeks at doses ranging from 450 to 2700 μg twice daily or 3712.5 μg once daily. Systemic dexamethasone (0.066 mg/kg per os) wa

SUBMITTER: Lavoie JP 

PROVIDER: S-EPMC7379559 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature