Ratios of specific IgG₄ over IgE antibodies do not improve prediction of peanut allergy nor of its severity compared to specific IgE alone.

ABSTRACT:

Background

IgG₄ antibodies have been suggested to play a protective role in the translation of peanut sensitization into peanut allergy. Whether they have added value as diagnostic read-out has not yet been reported.

Objective

To evaluate whether (a) peanut-specific IgG, IgG₄ and/or IgA antibodies are associated with tolerance and/or less severe reactions and (b) they can improve IgE-based diagnostic tests.

Methods

Sera of 137 patients with challenge-proven peanut allergy and of 25 subjects that tolerated peanut, both with known IgE profiles to peanut extract and five individual peanut allergens, were analyzed for specific IgG and IgG₄ . Antibody levels and ratios thereof were associated with challenge outcome including symptom severit

SUBMITTER: Datema MR 

PROVIDER: S-EPMC7379576 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature