Beneficial effect of butyrate-producing Lachnospiraceae on stress-induced visceral hypersensitivity in rats.

ABSTRACT:

Background and aim

Emerging evidence indicates that psychological stress is involved in the pathogenesis of irritable bowel syndrome, which is characterized by visceral hypersensitivity and may be accompanied by gut dysbiosis. However, how such stress contributes to the development of visceral hypersensitivity is incompletely understood. Here, we aimed to investigate the influence that stress-induced microbial changes exert on visceral sensitivity, as well as the possible underlying mechanisms associated with this effect.

Methods

Male Sprague-Dawley rats underwent chronic water avoidance stress (WAS) to induce visceral hypersensitivity. Visceral sensitivity, colonic tight junction protein expression, and short-chain fatty acids of cecal contents were measured. Fecal samples

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7379616 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature