Nucleotide receptor P2RY4 is required for head formation via induction and maintenance of head organizer in Xenopus laevis.

ABSTRACT: Vertebrates have unique head structures that are mainly composed of the central nervous system, the neural crest, and placode cells. These head structures are brought about initially by the neural induction between the organizer and the prospective neuroectoderm at early gastrula stage. Purinergic receptors are activated by nucleotides released from cells and influence intracellular signaling pathways, such as phospholipase C and adenylate cyclase signaling pathways. As P2Y receptor is vertebrate-specific and involved in head formation, we expect that its emergence may be related to the acquisition of vertebrate head during evolution. Here, we focused on the role of p2ry4 in early development in Xenopus laevis and found that p2ry4 was required for the establishment of the head organizer du

SUBMITTER: Harata A 

PROVIDER: S-EPMC7379700 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature