Transfusion-associated circulatory overload-a systematic review of diagnostic biomarkers.

ABSTRACT:

Background

Transfusion-associated circulatory overload (TACO) is the leading cause of transfusion-related major morbidity and mortality. Diagnosing TACO is difficult because there are no pathognomonic signs and symptoms. TACO biomarkers may aid in diagnosis, decrease time to treatment, and differentiate from other causes of posttransfusion dyspnea such a transfusion-related acute lung injury.

Study design and methods

A systematic review of literature was performed in EMBASE, PubMed, the TRIP Database, and the Cochrane Library, from inception to June 2018. All articles discussing diagnostic markers for TACO were included. Non-English articles or conference abstracts were excluded.

Results

Twenty articles discussing biomarkers for TACO were included. The majority invest

SUBMITTER: Klanderman RB 

PROVIDER: S-EPMC7379706 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature