Phenylketonuria screening in Iranian newborns: a systematic review and meta-analysis.

ABSTRACT:

Background

Phenylketonuria (PKU), which is characterized by a deficiency of phenylalanine hydroxylase activity, is an autosomal recessive disorder of phenylalanine (Phe) metabolism. Newborn screening is the main population-based public health screening program that allows successful identification and treatment of PKU with low-Phe diet. The aim of this study was to evaluate the epidemiology of PKU screening in Iranian newborns.

Methods

The present study was designed based on MOOSE protocol and reporting was done in accordance with the PRISMA guidelines. The protocol of this systematic review was published in PROSPERO before it was performed (CRD42020162626). A comprehensive search was done in 10/10/2019 to find related literature on international online databases Web of Scie

SUBMITTER: Shokri M 

PROVIDER: S-EPMC7379797 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature