Impact of prematurity and the CTG repeat length on outcomes in congenital myotonic dystrophy.

ABSTRACT:

Objective

Patients with congenital myotonic dystrophy (CDM) tend to be born preterm. Although the CDM severity generally depends on the CTG repeat length, prematurity may also affect the prognosis in patients with CDM. Given that preterm birth is expected to increase the risk of CDM in newborns, we investigated the outcomes of newborns with CDM according to gestational age to assess prematurity and the CTG repeat length for predicting prognosis.

Results

We assessed the outcomes of 54 infants with CDM using data collected from our hospitals and previously published studies. The patients were divided into mild and severe groups based on clinical outcomes. Logistic regression analysis was performed to estimate odds ratios (ORs) for CDM prognosis according to gestational age and

SUBMITTER: Saito Y 

PROVIDER: S-EPMC7379817 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature