Evaluation of a new West Nile virus nucleic acid test for screening of blood donations.

ABSTRACT:

Background

West Nile virus (WNV) is transmitted to humans through mosquito bites and can be further transmitted to humans through transfusion or transplantation. Because most infected individuals are asymptomatic, blood donor screening is important in areas where WNV is endemic. These studies evaluated the performance of a new test for detection of WNV RNA in blood donations.

Study design and methods

Analytical performance evaluation included sensitivity, specificity, inclusivity, and correlation. A clinical specificity study was conducted at four blood donor testing laboratories in parallel with the cobas TaqScreen WNV Test (Roche Molecular Systems, Inc.).

Results

The 95% and 50% limit of detection for cobas WNV was 12.9 copies/mL (95% confidence interval [CI], 10.8-

SUBMITTER: Stanley J 

PROVIDER: S-EPMC7379961 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature