Repeatability of ¹⁸ F-FDG PET radiomic features: A phantom study to explore sensitivity to image reconstruction settings, noise, and delineation method.

ABSTRACT:

Background

¹⁸ F-fluoro-2-deoxy-D-Glucose positron emission tomography (¹⁸ F-FDG PET) radiomics has the potential to guide the clinical decision making in cancer patients, but validation is required before radiomics can be implemented in the clinical setting. The aim of this study was to explore how feature space reduction and repeatability of ¹⁸ F-FDG PET radiomic features are affected by various sources of variation such as underlying data (e.g., object size and uptake), image reconstruction methods and settings, noise, discretization method, and delineation method.

Methods

The NEMA image quality phantom was scanned with various sphere-to-background ratios (SBR), simulating different activity uptakes, including spheres with low uptake, that

SUBMITTER: Pfaehler E 

PROVIDER: S-EPMC7380016 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature