The feasibility and efficacy of subcutaneous plerixafor for mobilization of peripheral blood stem cells in allogeneic HLA-identical sibling donors: results of the HOVON-107 study.

ABSTRACT:

Background

Plerixafor (PFX) mobilizes CD34+ cells into circulation by disrupting the CXCR4 binding of the hematopoietic stem cell in its bone marrow niche.

Study design and methods

in the prospective HOVON-107 study (www.hovon.nl) 23 allogeneic HLA-identical sibling donors received one or two subcutaneous (sc) injections of plerixafor 0.320 mg/kg.The primary endpoint, was defined as feasibility to mobilize a minimum of 2.0 x10⁶ CD34+ cells/kg recipient weight obtained by leukopheresis in at least 90% of the donors.

Results

median 3.3 x 10⁶ CD34⁺ cells/kg (1.9-6.5) were collected after 1 (n=12) or 2 (n=10) sc injections of PFX. Side effects occurred in 15/23 (65%) donors: most were grade 1-2; in 5 donors grade 3 and all resolved. All gr

SUBMITTER: de Greef GE 

PROVIDER: S-EPMC7380058 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature